Monthly Archives: August 2015

FoE mounts legal challenge to bee-killer pesticide permits

Friends of the Earth has applied for a judicial review of last month’s decision to allow farmers in England to use oilseed rape seeds coated with ‘neonics’ subject to an EU moratorium to protect bees.

Last month FoE demanded official information from the government on how it reached its decision to ‘derogate’ from the EU’s partial ban on the chemicals, and warned of possible legal action.

Three neonicotinoids were restricted throughout Europe in December 2013 after scientists warned that they harm bees. However, following a request by the NFU, the Government controversially agreed to allow farmers to use enough neonicotinoid seeds to grow 5% of the oilseed rape (OSR) crop in England, an area of around 30,000ha.

Currently neonic-treated seeds are being made available to farmers in Suffolk, Cambridgeshire, Bedfordshire and Hertfordshire for the autumn oilseed rape planting season. The seeds are marketed under the brand names Modesto (Bayer) and Cruiser OSR (Syngenta).

Ban did not accord with EU law

Friends of the Earth is challenging the decision to allow the pesticides because it believes the government failed to comply with EU law. Friends of the Earth bees campaigner Dave Timms said:

“We believe the government’s decision is unlawful because we believe they have not compled with the European law that sets down the conditions under which they can grant emergency use for a restricted neonicotinoid pesticide.”

The National Farmers Union application for ‘derogations’ on the EU’s partial ban on neonic seed treatments was granted by the Environment Secretary Lis Truss on 22nd July based on NFU claims of “widespread crop losses of oilseed rape crops due to infestation by cabbage stem flea beetles.”

However this year’s harvest has seen a good crop of oilseed rape despite the restrictions on neonicotinoids, with yields 3-9% higher than the 10 year national average – raising the question: where’s the emergency to justify breaking the ban?

While some fields have been seriously damaged by the cabbage stem flea beetle, which the neonic seed treatment is intended to combat, the charity Buglife believes the gain from more bees to pollinate the rapeseed flowers is greater than the loss.

“We seem to have forgotten that bees and other pollinators are essential to good crop yields”, said CEO Matt Shardlow. “In the trade off this year pollinators may have had a bigger positive effect than any negative impact of flea beetles.”

Moreover the flea beetle is just one of many causes of damage to oilseed rape crops. Other hazards to successful crop establishment include grazing by slugs and pigeons on the young plants, against which neonics are ineffective.

Scientific study adds to neonic fears

A study published in the journal Nature last week also found a significant link between neonic use and bee colony losses. Scientists combined “large-scale pesticide usage and yield observations from oilseed rape with those detailing honey bee colony losses over an 11 year period” to “reveal a correlation between honey bee colony losses and national-scale imidacloprid (a neonicotinoid) usage patterns across England and Wales.”

As the authors note, “neonicotinoid residues persist in plant tissues long enough to be detectable in OSR pollen and nectar, providing a potential route for mass exposure to pollinators. Indeed the N-nitroguanidine neonicotinoids have been linked experimentally to changes in pollinator foraging behaviour, reduced survival of individual insects, decelerated colony growth and in the case of bumble bees, colony failure.”

They also found evidence that farmers who use neonic seed coatings “may derive an economic return” by reducing the number of subsequent insecticide sprays – even though the seed treatments, which cause the pesticide to be expressed in pollen and nectar, cost three times more than spraying.

But FoE insists that the bees must come first. “We believe that allowing farmers to use these ‘banned’ pesticides is unnecessary, harmful and unlawful”, commented Timms. “These neonicotinoid pesticides have been restricted throughout the EU because scientists say they are harming bees, which are crucial for pollinating Britain’s fields, allotments and gardens.

“The Government should be listening to the science and championing the long-term interests of our threatened bees. The distribution of these seeds should now be halted until the courts can decide whether their use is lawful.”

 


 

Oliver Tickell edits The Ecologist.

 

Naked corruption: the scandal of glyphosate re-assessment in Europe

Germany, acting as the European Union rapporteur member state (RMS) submitted their glyphosate renewal assessment report (RAR) to the European Food Safety Authority (EFSA) in January 2014, recommending re-approval of glyphosate for use in Europe with increase in the acceptable daily intake (ADI) from 0.3 to 0.5 mg per kg body weight per day [1].

The overall findings of the RAR are that glyphosate poses no unacceptable risks. Glyphosate is not metabolized or accumulated in the body, not genotoxic, not carcinogenic, not endocrine disrupting, and not considered persistent or bioaccumulative.

It has no reproductive toxicity, no toxic effects on hormone-producing or hormone-dependent organs, and no unacceptable effect on bees. Therefore any risks are within ‘acceptable standards’. The only risks noted were that glyphosate is a severe eye irritant and persistent in soil.

We are yet to find out how the final decision will be affected by the WHO assessment of glyphosate as a ‘probable carcinogen’, though the Glyphosate Task Force involved in the renewal process (see later) have responded by stating they do not accept the decision [2].

Issues that could not be finalized in the assessment were: relevance of impurities, effects on microorganisms, effects on non-targeted plants, and indirect effects on biodiversity – non-targeted organisms, particularly birds. The Proposed Decision at the end of Vol. 1 is completely blacked out.

Scandalous conclusion amid overwhelming evidence of multiple toxicities

How did they arrive at such a preposterous conclusion when the evidence for glyphosate herbicides toxicity has accumulated worldwide to such an extent that a number of countries are already banning its use?

Denmark took the lead to ban the herbicide back in 2003 [3] The Dutch Parliament banned it in April 2014 for non-commercial use [4], to take effect by the end of 2015; France is set to follow.

Brazil, one of the largest growers of glyphosate-tolerant genetically modified (GM) crops has now filed a law suit by Federal Prosecutors to ban glyphosate along with eight other dangerous pesticides [5]. El Salvador imposed a complete ban in February 2013, linking glyphosate herbicides to an epidemic of chronic kidney disease that has struck the region [6].

Sri Lanka’s scientists have provided evidence for glyphosate accumulation in the body especially in the presence of hard water. Its ability to capture and retain arsenic and nephrotoxic metals enables it to act as a carrier to deliver the toxins to the kidney [7].

Glyphosate has also been linked to many other health problems including cancers, infertility, along with neurotoxicity, reproductive problems, birth defects, genotoxicity, and other human health problems as well as ecotoxicity, and many have considered a world-wide ban long overdue.

A deliberately restrictive consultation process

A severely restrictive electronic-only and biased comment process EFSA had put the RAR on their website for public consultation, which ended 11th May 2014. The response was electronic only on a rigid template with predetermined categories of answers, and severe limitations on space.

Neither e-mail, nor ordinary mail was accepted. Commenters had to sign an agreement to have their comments deleted if deemed unsuitable. Thus, all comments relating to Roundup were ignored, even though Roundup is the most widely used glyphosate herbicide in Europe. The consultation was strictly limited to pure glyphosate.

Dr Brian John of GM-Free Cymru lodged a complaint with the European Ombudsman saying that EFSA had no right to impose those conditions, accusing the process of being [8] “biased, and heavily weighted towards those who want to see glyphosate continue in use” and “entirely unfit for purpose.”

The entire process of risk assessment was also completely non-transparent. Who were the authors of the risk assessment report? The German Federal Institute for Risk Assessment (BfR– Bundesinstitut für Risikobewertung) is responsible for the RAR. There is no information on authorship anywhere within the 15 documents totalling 3,744 pages [9].

Between April and June of 2014, the BfR was contacted and asked on four separate occasions to provide information on who authored the report and which committee at BfR was responsible for the report. To date, they have not responded.

The BfR Committee for Pesticides and Their Residues (CPTR), which might be expected to be responsible for preparing the RAR, has 3 out of 12 of its 2014 members and four out of its 16 2011-2013 members from either BASF or Bayer CropScience [10, 11]. This serious conflict of interest in a regulatory agency is not restricted to BfR, it is endemic to the EU regulatory agency.

EFSA has a history of conflicts of interest. The Corporate Europe Observatory report ‘Unhappy Meal‘ published in October 2013 [12], revealed that some 59% of EFSA’s scientific panel members still had direct or indirect links to companies whose activities fell under EFSA’s remit.

As a result the European Parliament voted in April 2014 for a resolution to ban scientists with ties to the agriculture and food industries from working at the agency, and has given EFSA two years to clean up its act [13].

How did they arrive at such a preposterous conclusion when the evidence for glyphosate herbicides toxicity has accumulated worldwide to such an extent that a number of countries are already banning its use?

But the conflict of interest is even more blatant than anyone could have imagined. It is Monsanto and a consortium of European chemical companies that performed the risk assessment for the re-approval of glyphosate.

The risk assessors: Monsanto and a consortium of European chemical companies

The BfR stated in its press release [14]: “Apart from the BfR, other institutes involved in the new assessment of glyphosate were the Federal Environment Agency, the Julius Kühn Institute and the Federal Office of Consumer Protection and Food Safety, the latter as risk management authority.”

That was designed to add undue respectability and gravitas to the risk assessment. But BfR and its federal agency partners did not actually review the published toxicology studies. Instead they relied on a summary provided to them by the Glyphosate Task Force (GTF) [15].

And the GTF consists of Monsanto and a consortium of chemical companies all over Europe, including Syngenta UK and Dow Italy, with an odd one from Taiwan thrown in for good measure (see pp. 9-13 of Vol. 1 of the RAR [9]).

Although the BfR added comments here and there, all the assessments of the toxicological studies were from the GTF. Hence Monsanto and other companies who stood to gain from selling glyphosate herbicides were given free rein to pronounce glyphosate effectively even safer than before, hence the increase in ADI.

Let us be clear: even the industry’s studies found toxic effects for acute (single dose), subchronic (short-term) and chronic (long-term) exposures at some dosage. The way the game is played is to vary the dose and find the maximum dose where no adverse effects are observed (NOAL). Then divide that by 100 to obtain the ADI and declare the substance ‘safe’.

The chemical industries already knowthat glyphosate is toxic and can cause a host of physical problems.

Selective ‘expert’ rejection of counter-evidence

The GTF used a scheme devised by H.J. Klimisch and other scientists working for BASF in 1997 to assess the reliability of toxicological studies [16]. The method aims to classify toxicological data into one of four categories: reliable without restriction, reliable with restrictions, not reliable, and not assignable.

However, the assignment is weighted toward industry studies and is heavily dependent on the judgment of the human toxicologists involved. It can certainly not overcome human bias. Consequently, the rapporteur member state (RMS) has accepted, without question, virtually all of the unpublished reports given to them by the chemical companies.

Much of the information is blacked out (author, report title, laboratory) but the sponsoring company is named (Monsanto, Syngenta etc.) and the reports are referred to by a number. When the industry toxicology reports were in conflict with each other, they chose to sanction the ones that reported less toxic responses, relegating others to ‘supplementary’ status.

When the toxic effects were significant compared to their own controls, they used illicit ‘historical controls’ instead to make them appear less significant. Of the published reports, with the exception of genotoxicity, they only used those that tested for glyphosate alone.

The glyphosate was “supplied by Monsanto at 99% purity.” That, despite the fact that the public has been using nothing but formulations, especially Roundup!

Dissenting studies systematically weeded out

The GTF took all of the peer-reviewed studies and proceeded to find excuses to throw out the ones that didn’t agree with the already-accepted industry studies.

First they threw out all studies that used the actual product (Roundup, Rodeo, Lasso etc.) because the active ingredient percentage is not the same from product to product and the surfactants used vary from product to product so the results cannot be compared and are thus inconclusive.

They threw out any studies where they deemed that the dosage was unreasonably high, compared to their ‘safe’ levels, although their own toxicology studies showed the same results at the higher dosages.

They threw out any that they decided were inapplicable to mammals (frog embryos, insect larvae etc.) or that were administered in a non-natural way (injection). They took issue with how many rats / mice / dogs / guinea pigs were or were not used and how things were or were not measured or reported.

For human studies, the GTF argued that the dose / response could not be determined; the toxic effect could not be traced to glyphosate alone, the application rates were unreasonable for Europe, or there were reporting deficiencies of some sort. (For more details see a synopsis of the toxicology section of the RAR prepared by Nancy Swanson [17].)

The entire process of risk assessment for re-approval was flawed and corrupt to the core. It is rife with conflict of interest, non-transparent and heavily biased towards unpublished, non-peer reviewed studies from industry. The RAR is worse than useless, and should be rejected outright.

All available evidence including studies on commercial formulations of glyphosate herbicides should be seriously considered in any risk assessment, and by a truly independent, unbiased panel free from any conflict of interest.

 


 

This article is Chapter 11 of the report ‘Banishing Glyphosate‘ by Dr Eva Sirinathsinghji & Dr Mae-Wan Ho with Dr Medardo Ávila-Vázquez, Dr Don M. Huber, Dr Rosemary Mason, Ib Borup Pederson, Prof Peter Saunders, Dr Nancy Swanson, Production Editor Julian Haffegee.

The report:Banishing Glyphosate‘ is published in August 2015 by the Institute of Science in Society and is available from their website as a free download.

References

1. ‘Announcement of RAR‘ finalized on BfR website.

2. ‘Statement of the GTF on the recent IARC decision concerning glyphosate‘. Glyphosate.eu, accessed 25th June 2015.

3. Glyphosate, Wikibooks, 17 March 2013.

4. “Dutch Parliament bans Roundup, France and Brazil to follow”, The Healthy Home Economist, 12 April 2014, http://www.the-healthyhomeeconomist.com/roundup-banned-netherlands-france-brazil-likely-soon-follow/

5. ‘Brazil’s Federal Public Prosecutor Requests Total Ban of Glyphosate Herbicides‘. SustainablePulse.com, accessed 26th March 2014.

6. ‘El Salvador government bans Roundup over deadly kidney disease‘. Sustainablepulse.com, accessed 27th February 2014.

7. Jayasumana C, Gunatilake S, Senanayake P. ‘Glyphosate, hard water and nephrotoxic metals: are they the culprits behind the epidemic of chronic kidney disease of unknown etiology in Sri Lanka?International Journal of Environmental Research and Public Health 2014, 11, 2125-2147; doi:10.3390/ijerph110202125

8. ‘EFSA’s public consultation on glyphosate is entirely unfit for purpose‘. GM-Free Cymru, 23 May 2014.

9. Renewal Assessment Report on glyphosate (2014). Vol. 1. Report & proposed decision, 174 pages. Report and Proposed Decision. (Summary); Vol. 2 Annex A. List of tests & studies, 251 pages; Vol. 3 Annex B.1. Identity, 12 pages. (Molecular struc-ture and description); Vol. 3 Annex B.2. Physical & chemical properties, 41 pages; Vol. 3 Annex B.3. Data on application and further information, 30 pages. (Application rate, storage & handling); Vol. 3 Annex B.4. Proposals for the classification and labelling, 3 pages; Vol. 3 Annex B.5. Methods of analysis, 103 pages. (Analytical methods for determination of active sub-stance, impurities and residues); Vol. 3 Annex B.6.1. Toxicology and metabolism, 947 pages. (Animal and human toxicology); Vol. 3 Annex B.7. Residue data. 965 pages. (Crop residues); Vol. 3 Annex B.8. Environmental fate and behaviour, 361 pages; Vol. 3 Annex B.8 (Appendix). Evaluation of open literature regarding environmental fate and behaviour, 323 pages; Vol. 3 Annex B.9. Ecotoxicology, 314 pages; (Non-targeted plants, birds, fish and other creatures); Vol. 3 Annex B.9 (Appendix). Evaluation of peer-reviewed literature on ecotoxicology, 201 pages; List of endpoints, 77 pages; List of information, tests and studies which are considered as relied upon by the RMS for evaluation, 143 pages. (This document has been taken down from the website after 11 May, but one of us has kept a copy.)

10. ‘2014 members of BfR Committee for Pesticides and Their Residues‘.

11. ‘2011-13 members of BfR Committee for Pesticides and Their Residues‘.

12. ‘Unhappy meal. The European Food Safety Authority’s independence problem‘. Corporate Europe Observatory, 23 October 2013.

13.’The European Parliament demands stricter regulation of conflicts of interest at EU’s food safety authority‘, Corporate Europe Observatory, 3 April 2014.

14. ‘Glyphosate: no more poisonous than previously assumed, although a critical view should be taken of certain co-formulants‘. BfR website.

15. Glyphosate facts: ‘Transparency on safety aspects and use of glyphosate-containing herbicides in Europe‘. Accessed 7 July 2014.

16. Klimisch score. Wikipedia, 19 August 2012.

17. Swanson N., ‘Glyphosate re-assessment in Europe is corrupt‘, 8 July 2014.

 

Warmer winters boost Europe’s wild boar

Wild boar populations in Europe are getting out of control – and scientists are blaming climate change.

There are now millions of wild boar spreading out from their preferred woodland habitat, moving into city suburbs, and even crossing national boundaries to countries that had thought they were extinct.

In some countries, notably France and Germany, which have always had wild boar populations in their forests, they are a major cause of road accidents.

France has an estimated two million boar, and the German state of Hesse alone has 180,000. Berlin, the German capital, is erecting boar fencing around its borders in an attempt to keep the animals out of the city.

Scientists from the Research Institute for Wildlife Ecology at the University of Veterinary Medicine in Vienna, Austria, report in the journal PLOS ONE that they chose the animal to study because “the wild boar has an enormous reproductive capacity, and thus the potential for remarkable population growth when environmental conditions become more favourable.”

Wild boar can have five or more young in a litter, can live as long as 12 years, and females can reach sexual maturity within their first year if there is plenty of food available.

Warmer weather means more nuts and acorns

The scientists believe that the increasingly frequent mild winters in Europe and the extra production of acorns and beechnuts by trees are aiding boar survival rates. Both factors are the result of climate change, they say.

The number of animals has been increasing since the 1980s. Because boars are secretive, nocturnal animals, the scientists had to use hunting records and road accidents to help count the animals in 12 European countries.

“Doing this, we were able to depict the growth of the wild boar population”, says the report’s lead author, Sebastian Vetter, an evolutionary biologist. “As mild winters are becoming more frequent, boar populations are also growing exponentially.”

Climate change is also having a direct effect on food supply, the authors say, with the increasing frequency of ‘mast years’ – years when trees produce huge quantities of acorns and nuts – also aiding the animals’ survival. They attribute the phenomenon to warming climate.

In severe winters, a large number of young from the previous summer used to die of cold and hunger, but the extra food supply available, even in cold spells, is enabling more to survive.

“Our analysis showed that the frequency of beech masting years has increased over the last decades, presumably due to climate change. This finding, together with the fact that cold winters had no negative effect on population growth when food resources were abundant, shows that the effect of climate change on population growth of wild boar is two-fold:

“Cold winters have become rarer and, on top of this, the remaining severe winters became increasingly ineffective in diminishing wild boar populations because of the increasing frequency of masting years. In such years, beech or oak trees produce vast amounts of energy rich seeds that are available from autumn until spring in the following year.

“If abundant, this food source likely enables juveniles to cope even with high thermoregulatory costs in a severe winter, and adults to accumulate high amounts of body energy reserves for reproduction in the following year. This result also indicates that low survival in cold winters is apparently not caused by a limited thermogenic capacity.

“Instead, increased winter mortality seems to be caused by a negative energy balance, i.e., when high thermoregulatory costs, due to severe cold, cannot be matched by the available food, especially when high caloric seeds are absent.”

From Italy to Sweden, populations surge

Wild boars are one of the most widely distributed of animals, with their numbers varying between northern and southern latitudes. However, the survival rate of boar populations in Europe seems to be increasing across all countries.

One of the reasons for the wider spread of boar populations has been the fashion for their meat. Wild boar farms have been established in countries where the species had long ago been hunted to extinction. But farmers, unfamiliar with the animals, were not prepared for their ability to break down or jump fences as high as two metres, and many boars escaped into the wild.

Sweden, for example, had no wild boar 10 years ago, but now has an estimated 150,000 in its forests. The UK also has a small but well-entrenched boar population for the first time in 500 years.

Italy, well to the south, has always had wild boar, but has also seen a huge growth in their numbers. There are now estimated to be between 600,000 and 1 million animals. Some are seen on the outskirts of Rome, Genoa and Naples, where they eat from dustbins.

 


 

The paper:What Is a Mild Winter? Regional Differences in Within-Species Responses to Climate Change‘ by Sebastian G. Vetter, Thomas Ruf, Claudia Bieber, Walter Arnold is published in PLOS One.

Paul Brown writes for Climate News Network.

 

Roundup may cause potentially fatal ‘adrenal insufficiency’

Monsanto’s glyphosate-based herbicide Roundup is an endocrine (hormone) disruptor in adult male rats, a new study shows.

The lowest dose tested of 10 mg/kg bw/d (bodyweight per day) was found to reduce levels of corticosterone, a steroid hormone produced in the adrenal glands. This was only one manifestation of a widespread disruption of adrenal function.

No other toxic effects were seen at that dose, so if endocrine disruption were not being specifically looked for, there would be no other signs that the dose was toxic. However a 2012 study detected a 35% testosterone down-regulation in rats at a concentration of 1 part per million.

In both studies endocrine disruption was detected at the lowest level tested for, so we don’t know if, when it comes to endocrine disruption, there are ‘safe’ lower doses of Roundup. In technical parlance, this means that no NOAEL (no observed adverse effect level), was found.

Significantly, the authors believe that the hormonal disruption could lead to the potentially fatal condition know as ‘adrenal insufficiency‘ in humans, which causes fatigue, anorexia, sweating, anxiety, shaking, nausea, heart palpitations and weight loss.

“A progressive increase in its prevalence has been observed in humans, while a very few studies relating to xenobiotic exposure and adrenal insufficiency development have been reported”, they write. The increasing levels of Roundup in the environment and food could be “one of the possible mechanisms of adrenal insufficiency.”

How does this level relate to safety limits set by regulators?

One problem with trying to work out how the endocrine disruptive level of 10 mg/kg bw/d relates to how ‘safe’ levels are set by regulators.

The experiment looked at Roundup, the complete herbicide formulation as sold and used, but regulators only look at the long-term safety of glyphosate alone, the supposed active ingredient of Roundup.

Safe levels for chronic exposure to the Roundup herbicide product have never been tested or assessed for regulatory processes. This is a serious omission because Roundup has been shown in many tests to be more disruptive to hormones than glyphosate alone, thanks to the numerous other ingredients it contains to enhance its weed-killing properties.

Given this yawning data gap, let’s for a moment assume that the regulatory limits set for glyphosate alone can be used as a guide for the safe level of Roundup.

The endocrine disruptive level of Roundup found in the experiment, of 10 mg/kg bw/d, is is well above the acceptable daily intake (ADI) set for glyphosate in Europe (0.3 mg/kg bw/d) and the US (1.75 mg/kg bw/d). But this isn’t a reason to feel reassured, since with endocrine effects, low doses can be more disruptive than higher doses.

Another worrying factor is that 10 mg/kg bw/d is well below the NOAEL (no observed adverse effect level) for chronic toxicity of glyphosate: 500 mg/kg bw/d for chronic toxicity, according to the US EPA.

In other words, the level of 500 mg/kg bw/d – a massive 50 times higher than the level of Roundup found to be endocrine disruptive in the experiment – is deemed by US regulators not to cause chronic toxicity.

This experiment shows they are wrong by a long shot. They failed to see toxicity below that level because they failed to take endocrine disruptive effects from low doses into account and industry does not test for them.

Hormone disruption take place at or below ‘no adverse effects’ levels

Interestingly, the NOAEL for glyphosate in industry’s three-generation reproductive studies in rats was much lower than that for chronic toxicity – 30 mg/kg bw/day for adults and 10 mg/kg bw/day for offspring.

However the latter figures – at which no adverse effects should be apparent from glyphosate – are at the same as or higher level than the level of Roundup found to be endocrine disruptive in the new study.

These results therefore show that the reproductive processes of the rats are sensitive to low doses that are apparently not overtly toxic. This in turn suggests that the reproductive toxicity findings are due to endocrine disruptive effects.

Regulatory tests still do not include tests for endocrine disruption from low doses, in spite of the fact that scientists have known about the syndrome since the 1990s.

In the final section of the new study, the researchers discuss its implications. They note that the effects seen in the Roundup-treated rats to the Adrenocorticotropic hormone receptor (ACTH) were similar to adrenal insufficiency in humans:

“The findings that Roundup treatment down regulates endogenous ACTH, is similar to the condition known as adrenal insufficiency in humans. This condition manifests as fatigue, anorexia, sweating, anxiety, shaking, nausea, heart palpitations and weight loss. Chronic adrenal insufficiency could be fatal, if untreated.

“A progressive increase in its prevalence has been observed in humans, while a very few studies relating to xenobiotic exposure and adrenal insufficiency development have been reported. The present study describes one of the possible mechanisms of adrenal insufficiency due to Roundupand suggests more systematic studies, to investigate the area further. “

Claire Robinson of GMWatch commented: “Since no safe dose has been established for Roundup with regard to endocrine disrupting effects, it should be banned.”

 


 

The study:Analysis of endocrine disruption effect of Roundup in adrenal gland of male rats‘ is by Aparamita Pandey and Medhamurthy Rudraiah, and published in Toxicology Reports 2 (2015) pp.1075-1085 on open access.

This article was originally published by GMWatch. This version has been subject to some edits and additions by The Ecologist.

 

Into the heart of the beast – occupying Germany’s open cast coal nightmare

Last weekend I along with around one thousand other people took part in mass direct action against one of the largest open cast lignite mines in Europe, owned by RWE, which along with surrounding mines and coal powers stations is the largest source of greenhouse gases in Europe.

I took part because fossil fuel capitalism is destroying our Earth. Waiting for companies and governments to do the right things is not working and is not going to work so people must stand up and force them to.

Earlier this year, the German government caved in to the lobbying might of RWE, backtracking on plans to put a levy on the most polluting power plants, which would have led to a phase out of lignite. Last weekend, people stood up in protest to say ‘Ende Gelände’, here and no further.

This is my experience of the day. It was a long, exhausting and confused day, and what I experienced will not be the same thing that others in different parts of the action experienced. But I hope this can help anyone reading understand what happened.

The assault

“Guten Morgen, Ende Gelände!” Those were the words I woke up to at 5:45 am in my tent. An early start for a momentous day, I rushed to scramble my stuff together, go to the loo and then hastily join up with my affinity group.

We were in the ‘Green Finger’ one of the four groups with approximately 250 people in them, that would be laying siege to the mine.

When the whole finger was formed up with everyone in their agreed place, my affinity group was in the middle. The first kilometre or so passed calmly enough. I could even hear someone play ‘The Diggers Song’ on a pipe, as we searched for a way across the motorway between us and the mine.

In the end, we came upon a tunnel with only about four lines of cops blocking it. It was at this point that many people there had their first experience of police violence, in some ways I was lucky I knew what to expect from previous actions.

This is where the battle began. The nail of the finger pushed through the police line, some using sacks of straw as shields to protect themselves. The police tried to stand firm but couldn’t hold back our momentum.

So they resorted to filling the air with a mist of pepper spray and beating everyone they could reach with their clubs, in the hope of separating them from the group. Everyone around me bunched up like rugby players in a scrum so the police couldn’t drag any of us away.

After this came a mad dash across the fields going through two more police lines. Even when they weren’t in front of us, the police followed behind us on foot and in vans trying to beat and pick off any stragglers. One person in my affinity group got pepper spray in their face, so we had to guide him by hand as we ran through a break in the police line.

I’m humbled by the trust he showed in us to make sure he wasn’t beaten to a pulp. The way everyone rallied to help those around them who had been beaten or pepper sprayed was one the most beautiful displays of practical solidarity I had ever seen.

Into the mine

After we successfully got across the fields, we walked along a dirt track by the edge of the mine that was in line with some water sprinklers used to stop dust escaping. Before this point I hadn’t really grasped the scale of the place. It looked large enough to fit at least two good sized towns in. It went from sand coloured at the top down to pitch black at the bottom.

We descended down the mine on a sandy ramp wide enough to drive a van down. At a bend near the bottom there was an attempt to block the path, but we evaded the police by travelling out the bank and bypassing them instead.

We then moved as fast as we could along the top tier of the mine, shadowed by a group of riot cops on the cliff top. When we reached one of the corners of the top tier, where conveyor belts over a kilometre long ended, we met a small group of security, which most of us were able to get past without much trouble. As we moved along the side of the conveyor belt towards one of the massive Baggers the police raced after us in borrowed 4x4s.

The police tried to form a line to block us off, but there were too few of them to do anything, so we were able to bust through the line with ease. My legs were burning from running in the sand with a heavy bag full of water. My right arm felt like it was on fire from the pepper spray.

After this we formed a line in order to stop any more police being able to join those in front of us. They tried again to block our path, but we held our line together by linking arms. We successfully stood our ground and they were forced to retreat. Seeing the police retreat was a wonderful sight.

Eventually we came to a point that was too wide for us to fully block and even more police managed to get past us. They had a much stronger line in front of us, which was thickest next to the conveyor belt where I was walking. On the very far side from me people managed to break through their line next to some smaller diggers.

The members of the affinity group I was with tried to run over to flow through the police, but by the time we got there they had closed it. I saw one police officer grab someone by their front and beat them across their back, while others lashed wildly in every direction, and others pepper-sprayed around them hoping to burn someone.

Detention

After two hours, roughly seven kilometres, and numerous police lines, we were kettled at 9 am. Even then we were still winning, as just by being there we stopped the mine from running and the police guarding us couldn’t work to keep others out.

We could see the Baggers lying still while in the distance wind turbines moved. A couple of hours in, they started to pull us out one by one, taking our photos and trying to get our names. Almost no one told them.

After this, they tied our hands with zip ties behind our backs. Through all this we supported each other, and worked to keep our spirits up by playing games and chatting (small talk when you can’t say your name, or say too much about yourself is strange).

After five to seven hours we were moved onto buses and taken to a police station. We sat for several more hours chatting, singing and sharing food (our hands had been freed by then). Eventually, they gave up on trying to process several hundred people that refused to give their names and resisted having their fingerprints taken.

Around 11 pm we were dumped outside a railway station and made our way back to camp, tired but triumphant. For the train ride back, some of us brought a couple of crates of beer, we celebrated the day and talked about what we’d been through on the train back. By around 1 am I was back in my tent exhausted, sore, emotionally drained, but also felt great about what we’d done together and achieved.

We had stopped the diggers for a day but it was also about more than just that. In economic terms it will have also damaged RWE’s position on the market (their share price just hit a new low) and made them seem less trustworthy to investors.

In addition to this many there had never taken part in direct action before but now know that by working together and taking matters into our own hands we can achieve more than waiting for salvation from those above us in society could ever do.

Many people both there and watching the events from afar will also have seen the role of the police, not as keeping of the peace but as guard dogs of social and economic order which is killing us and our planet. Last weekend, we fought and we won.

 


 

Background to the action:Power struggle: after Germany’s renewables surge, can it keep its coal in the ground?‘ by Melanie Mattauch.

Toni Belly is a student at the University of Birmingham and a member of Plan C. He is also active in various student political and campaigning groups fighting on both environmental and economic issues. He’s critical of solutions to economic, social and environmental issues that rely on benevolent action on the part of those at the top of our current social economic order. Instead being of the view that real change can only come through struggle enacted from below.

 

Warmer winters boost Europe’s wild boar

Wild boar populations in Europe are getting out of control – and scientists are blaming climate change.

There are now millions of wild boar spreading out from their preferred woodland habitat, moving into city suburbs, and even crossing national boundaries to countries that had thought they were extinct.

In some countries, notably France and Germany, which have always had wild boar populations in their forests, they are a major cause of road accidents.

France has an estimated two million boar, and the German state of Hesse alone has 180,000. Berlin, the German capital, is erecting boar fencing around its borders in an attempt to keep the animals out of the city.

Scientists from the Research Institute for Wildlife Ecology at the University of Veterinary Medicine in Vienna, Austria, report in the journal PLOS ONE that they chose the animal to study because “the wild boar has an enormous reproductive capacity, and thus the potential for remarkable population growth when environmental conditions become more favourable.”

Wild boar can have five or more young in a litter, can live as long as 12 years, and females can reach sexual maturity within their first year if there is plenty of food available.

Warmer weather means more nuts and acorns

The scientists believe that the increasingly frequent mild winters in Europe and the extra production of acorns and beechnuts by trees are aiding boar survival rates. Both factors are the result of climate change, they say.

The number of animals has been increasing since the 1980s. Because boars are secretive, nocturnal animals, the scientists had to use hunting records and road accidents to help count the animals in 12 European countries.

“Doing this, we were able to depict the growth of the wild boar population”, says the report’s lead author, Sebastian Vetter, an evolutionary biologist. “As mild winters are becoming more frequent, boar populations are also growing exponentially.”

Climate change is also having a direct effect on food supply, the authors say, with the increasing frequency of ‘mast years’ – years when trees produce huge quantities of acorns and nuts – also aiding the animals’ survival. They attribute the phenomenon to warming climate.

In severe winters, a large number of young from the previous summer used to die of cold and hunger, but the extra food supply available, even in cold spells, is enabling more to survive.

“Our analysis showed that the frequency of beech masting years has increased over the last decades, presumably due to climate change. This finding, together with the fact that cold winters had no negative effect on population growth when food resources were abundant, shows that the effect of climate change on population growth of wild boar is two-fold:

“Cold winters have become rarer and, on top of this, the remaining severe winters became increasingly ineffective in diminishing wild boar populations because of the increasing frequency of masting years. In such years, beech or oak trees produce vast amounts of energy rich seeds that are available from autumn until spring in the following year.

“If abundant, this food source likely enables juveniles to cope even with high thermoregulatory costs in a severe winter, and adults to accumulate high amounts of body energy reserves for reproduction in the following year. This result also indicates that low survival in cold winters is apparently not caused by a limited thermogenic capacity.

“Instead, increased winter mortality seems to be caused by a negative energy balance, i.e., when high thermoregulatory costs, due to severe cold, cannot be matched by the available food, especially when high caloric seeds are absent.”

From Italy to Sweden, populations surge

Wild boars are one of the most widely distributed of animals, with their numbers varying between northern and southern latitudes. However, the survival rate of boar populations in Europe seems to be increasing across all countries.

One of the reasons for the wider spread of boar populations has been the fashion for their meat. Wild boar farms have been established in countries where the species had long ago been hunted to extinction. But farmers, unfamiliar with the animals, were not prepared for their ability to break down or jump fences as high as two metres, and many boars escaped into the wild.

Sweden, for example, had no wild boar 10 years ago, but now has an estimated 150,000 in its forests. The UK also has a small but well-entrenched boar population for the first time in 500 years.

Italy, well to the south, has always had wild boar, but has also seen a huge growth in their numbers. There are now estimated to be between 600,000 and 1 million animals. Some are seen on the outskirts of Rome, Genoa and Naples, where they eat from dustbins.

 


 

The paper:What Is a Mild Winter? Regional Differences in Within-Species Responses to Climate Change‘ by Sebastian G. Vetter, Thomas Ruf, Claudia Bieber, Walter Arnold is published in PLOS One.

Paul Brown writes for Climate News Network.

 

Roundup may cause potentially fatal ‘adrenal insufficiency’

Monsanto’s glyphosate-based herbicide Roundup is an endocrine (hormone) disruptor in adult male rats, a new study shows.

The lowest dose tested of 10 mg/kg bw/d (bodyweight per day) was found to reduce levels of corticosterone, a steroid hormone produced in the adrenal glands. This was only one manifestation of a widespread disruption of adrenal function.

No other toxic effects were seen at that dose, so if endocrine disruption were not being specifically looked for, there would be no other signs that the dose was toxic. However a 2012 study detected a 35% testosterone down-regulation in rats at a concentration of 1 part per million.

In both studies endocrine disruption was detected at the lowest level tested for, so we don’t know if, when it comes to endocrine disruption, there are ‘safe’ lower doses of Roundup. In technical parlance, this means that no NOAEL (no observed adverse effect level), was found.

Significantly, the authors believe that the hormonal disruption could lead to the potentially fatal condition know as ‘adrenal insufficiency‘ in humans, which causes fatigue, anorexia, sweating, anxiety, shaking, nausea, heart palpitations and weight loss.

“A progressive increase in its prevalence has been observed in humans, while a very few studies relating to xenobiotic exposure and adrenal insufficiency development have been reported”, they write. The increasing levels of Roundup in the environment and food could be “one of the possible mechanisms of adrenal insufficiency.”

How does this level relate to safety limits set by regulators?

One problem with trying to work out how the endocrine disruptive level of 10 mg/kg bw/d relates to how ‘safe’ levels are set by regulators.

The experiment looked at Roundup, the complete herbicide formulation as sold and used, but regulators only look at the long-term safety of glyphosate alone, the supposed active ingredient of Roundup.

Safe levels for chronic exposure to the Roundup herbicide product have never been tested or assessed for regulatory processes. This is a serious omission because Roundup has been shown in many tests to be more disruptive to hormones than glyphosate alone, thanks to the numerous other ingredients it contains to enhance its weed-killing properties.

Given this yawning data gap, let’s for a moment assume that the regulatory limits set for glyphosate alone can be used as a guide for the safe level of Roundup.

The endocrine disruptive level of Roundup found in the experiment, of 10 mg/kg bw/d, is is well above the acceptable daily intake (ADI) set for glyphosate in Europe (0.3 mg/kg bw/d) and the US (1.75 mg/kg bw/d). But this isn’t a reason to feel reassured, since with endocrine effects, low doses can be more disruptive than higher doses.

Another worrying factor is that 10 mg/kg bw/d is well below the NOAEL (no observed adverse effect level) for chronic toxicity of glyphosate: 500 mg/kg bw/d for chronic toxicity, according to the US EPA.

In other words, the level of 500 mg/kg bw/d – a massive 50 times higher than the level of Roundup found to be endocrine disruptive in the experiment – is deemed by US regulators not to cause chronic toxicity.

This experiment shows they are wrong by a long shot. They failed to see toxicity below that level because they failed to take endocrine disruptive effects from low doses into account and industry does not test for them.

Hormone disruption take place at or below ‘no adverse effects’ levels

Interestingly, the NOAEL for glyphosate in industry’s three-generation reproductive studies in rats was much lower than that for chronic toxicity – 30 mg/kg bw/day for adults and 10 mg/kg bw/day for offspring.

However the latter figures – at which no adverse effects should be apparent from glyphosate – are at the same as or higher level than the level of Roundup found to be endocrine disruptive in the new study.

These results therefore show that the reproductive processes of the rats are sensitive to low doses that are apparently not overtly toxic. This in turn suggests that the reproductive toxicity findings are due to endocrine disruptive effects.

Regulatory tests still do not include tests for endocrine disruption from low doses, in spite of the fact that scientists have known about the syndrome since the 1990s.

In the final section of the new study, the researchers discuss its implications. They note that the effects seen in the Roundup-treated rats to the Adrenocorticotropic hormone receptor (ACTH) were similar to adrenal insufficiency in humans:

“The findings that Roundup treatment down regulates endogenous ACTH, is similar to the condition known as adrenal insufficiency in humans. This condition manifests as fatigue, anorexia, sweating, anxiety, shaking, nausea, heart palpitations and weight loss. Chronic adrenal insufficiency could be fatal, if untreated.

“A progressive increase in its prevalence has been observed in humans, while a very few studies relating to xenobiotic exposure and adrenal insufficiency development have been reported. The present study describes one of the possible mechanisms of adrenal insufficiency due to Roundupand suggests more systematic studies, to investigate the area further. “

Claire Robinson of GMWatch commented: “Since no safe dose has been established for Roundup with regard to endocrine disrupting effects, it should be banned.”

 


 

The study:Analysis of endocrine disruption effect of Roundup in adrenal gland of male rats‘ is by Aparamita Pandey and Medhamurthy Rudraiah, and published in Toxicology Reports 2 (2015) pp.1075-1085 on open access.

This article was originally published by GMWatch. This version has been subject to some edits and additions by The Ecologist.

 

Into the heart of the beast – occupying Germany’s open cast coal nightmare

Last weekend I along with around one thousand other people took part in mass direct action against one of the largest open cast lignite mines in Europe, owned by RWE, which along with surrounding mines and coal powers stations is the largest source of greenhouse gases in Europe.

I took part because fossil fuel capitalism is destroying our Earth. Waiting for companies and governments to do the right things is not working and is not going to work so people must stand up and force them to.

Earlier this year, the German government caved in to the lobbying might of RWE, backtracking on plans to put a levy on the most polluting power plants, which would have led to a phase out of lignite. Last weekend, people stood up in protest to say ‘Ende Gelände’, here and no further.

This is my experience of the day. It was a long, exhausting and confused day, and what I experienced will not be the same thing that others in different parts of the action experienced. But I hope this can help anyone reading understand what happened.

The assault

“Guten Morgen, Ende Gelände!” Those were the words I woke up to at 5:45 am in my tent. An early start for a momentous day, I rushed to scramble my stuff together, go to the loo and then hastily join up with my affinity group.

We were in the ‘Green Finger’ one of the four groups with approximately 250 people in them, that would be laying siege to the mine.

When the whole finger was formed up with everyone in their agreed place, my affinity group was in the middle. The first kilometre or so passed calmly enough. I could even hear someone play ‘The Diggers Song’ on a pipe, as we searched for a way across the motorway between us and the mine.

In the end, we came upon a tunnel with only about four lines of cops blocking it. It was at this point that many people there had their first experience of police violence, in some ways I was lucky I knew what to expect from previous actions.

This is where the battle began. The nail of the finger pushed through the police line, some using sacks of straw as shields to protect themselves. The police tried to stand firm but couldn’t hold back our momentum.

So they resorted to filling the air with a mist of pepper spray and beating everyone they could reach with their clubs, in the hope of separating them from the group. Everyone around me bunched up like rugby players in a scrum so the police couldn’t drag any of us away.

After this came a mad dash across the fields going through two more police lines. Even when they weren’t in front of us, the police followed behind us on foot and in vans trying to beat and pick off any stragglers. One person in my affinity group got pepper spray in their face, so we had to guide him by hand as we ran through a break in the police line.

I’m humbled by the trust he showed in us to make sure he wasn’t beaten to a pulp. The way everyone rallied to help those around them who had been beaten or pepper sprayed was one the most beautiful displays of practical solidarity I had ever seen.

Into the mine

After we successfully got across the fields, we walked along a dirt track by the edge of the mine that was in line with some water sprinklers used to stop dust escaping. Before this point I hadn’t really grasped the scale of the place. It looked large enough to fit at least two good sized towns in. It went from sand coloured at the top down to pitch black at the bottom.

We descended down the mine on a sandy ramp wide enough to drive a van down. At a bend near the bottom there was an attempt to block the path, but we evaded the police by travelling out the bank and bypassing them instead.

We then moved as fast as we could along the top tier of the mine, shadowed by a group of riot cops on the cliff top. When we reached one of the corners of the top tier, where conveyor belts over a kilometre long ended, we met a small group of security, which most of us were able to get past without much trouble. As we moved along the side of the conveyor belt towards one of the massive Baggers the police raced after us in borrowed 4x4s.

The police tried to form a line to block us off, but there were too few of them to do anything, so we were able to bust through the line with ease. My legs were burning from running in the sand with a heavy bag full of water. My right arm felt like it was on fire from the pepper spray.

After this we formed a line in order to stop any more police being able to join those in front of us. They tried again to block our path, but we held our line together by linking arms. We successfully stood our ground and they were forced to retreat. Seeing the police retreat was a wonderful sight.

Eventually we came to a point that was too wide for us to fully block and even more police managed to get past us. They had a much stronger line in front of us, which was thickest next to the conveyor belt where I was walking. On the very far side from me people managed to break through their line next to some smaller diggers.

The members of the affinity group I was with tried to run over to flow through the police, but by the time we got there they had closed it. I saw one police officer grab someone by their front and beat them across their back, while others lashed wildly in every direction, and others pepper-sprayed around them hoping to burn someone.

Detention

After two hours, roughly seven kilometres, and numerous police lines, we were kettled at 9 am. Even then we were still winning, as just by being there we stopped the mine from running and the police guarding us couldn’t work to keep others out.

We could see the Baggers lying still while in the distance wind turbines moved. A couple of hours in, they started to pull us out one by one, taking our photos and trying to get our names. Almost no one told them.

After this, they tied our hands with zip ties behind our backs. Through all this we supported each other, and worked to keep our spirits up by playing games and chatting (small talk when you can’t say your name, or say too much about yourself is strange).

After five to seven hours we were moved onto buses and taken to a police station. We sat for several more hours chatting, singing and sharing food (our hands had been freed by then). Eventually, they gave up on trying to process several hundred people that refused to give their names and resisted having their fingerprints taken.

Around 11 pm we were dumped outside a railway station and made our way back to camp, tired but triumphant. For the train ride back, some of us brought a couple of crates of beer, we celebrated the day and talked about what we’d been through on the train back. By around 1 am I was back in my tent exhausted, sore, emotionally drained, but also felt great about what we’d done together and achieved.

We had stopped the diggers for a day but it was also about more than just that. In economic terms it will have also damaged RWE’s position on the market (their share price just hit a new low) and made them seem less trustworthy to investors.

In addition to this many there had never taken part in direct action before but now know that by working together and taking matters into our own hands we can achieve more than waiting for salvation from those above us in society could ever do.

Many people both there and watching the events from afar will also have seen the role of the police, not as keeping of the peace but as guard dogs of social and economic order which is killing us and our planet. Last weekend, we fought and we won.

 


 

Background to the action:Power struggle: after Germany’s renewables surge, can it keep its coal in the ground?‘ by Melanie Mattauch.

Toni Belly is a student at the University of Birmingham and a member of Plan C. He is also active in various student political and campaigning groups fighting on both environmental and economic issues. He’s critical of solutions to economic, social and environmental issues that rely on benevolent action on the part of those at the top of our current social economic order. Instead being of the view that real change can only come through struggle enacted from below.

 

Warmer winters boost Europe’s wild boar

Wild boar populations in Europe are getting out of control – and scientists are blaming climate change.

There are now millions of wild boar spreading out from their preferred woodland habitat, moving into city suburbs, and even crossing national boundaries to countries that had thought they were extinct.

In some countries, notably France and Germany, which have always had wild boar populations in their forests, they are a major cause of road accidents.

France has an estimated two million boar, and the German state of Hesse alone has 180,000. Berlin, the German capital, is erecting boar fencing around its borders in an attempt to keep the animals out of the city.

Scientists from the Research Institute for Wildlife Ecology at the University of Veterinary Medicine in Vienna, Austria, report in the journal PLOS ONE that they chose the animal to study because “the wild boar has an enormous reproductive capacity, and thus the potential for remarkable population growth when environmental conditions become more favourable.”

Wild boar can have five or more young in a litter, can live as long as 12 years, and females can reach sexual maturity within their first year if there is plenty of food available.

Warmer weather means more nuts and acorns

The scientists believe that the increasingly frequent mild winters in Europe and the extra production of acorns and beechnuts by trees are aiding boar survival rates. Both factors are the result of climate change, they say.

The number of animals has been increasing since the 1980s. Because boars are secretive, nocturnal animals, the scientists had to use hunting records and road accidents to help count the animals in 12 European countries.

“Doing this, we were able to depict the growth of the wild boar population”, says the report’s lead author, Sebastian Vetter, an evolutionary biologist. “As mild winters are becoming more frequent, boar populations are also growing exponentially.”

Climate change is also having a direct effect on food supply, the authors say, with the increasing frequency of ‘mast years’ – years when trees produce huge quantities of acorns and nuts – also aiding the animals’ survival. They attribute the phenomenon to warming climate.

In severe winters, a large number of young from the previous summer used to die of cold and hunger, but the extra food supply available, even in cold spells, is enabling more to survive.

“Our analysis showed that the frequency of beech masting years has increased over the last decades, presumably due to climate change. This finding, together with the fact that cold winters had no negative effect on population growth when food resources were abundant, shows that the effect of climate change on population growth of wild boar is two-fold:

“Cold winters have become rarer and, on top of this, the remaining severe winters became increasingly ineffective in diminishing wild boar populations because of the increasing frequency of masting years. In such years, beech or oak trees produce vast amounts of energy rich seeds that are available from autumn until spring in the following year.

“If abundant, this food source likely enables juveniles to cope even with high thermoregulatory costs in a severe winter, and adults to accumulate high amounts of body energy reserves for reproduction in the following year. This result also indicates that low survival in cold winters is apparently not caused by a limited thermogenic capacity.

“Instead, increased winter mortality seems to be caused by a negative energy balance, i.e., when high thermoregulatory costs, due to severe cold, cannot be matched by the available food, especially when high caloric seeds are absent.”

From Italy to Sweden, populations surge

Wild boars are one of the most widely distributed of animals, with their numbers varying between northern and southern latitudes. However, the survival rate of boar populations in Europe seems to be increasing across all countries.

One of the reasons for the wider spread of boar populations has been the fashion for their meat. Wild boar farms have been established in countries where the species had long ago been hunted to extinction. But farmers, unfamiliar with the animals, were not prepared for their ability to break down or jump fences as high as two metres, and many boars escaped into the wild.

Sweden, for example, had no wild boar 10 years ago, but now has an estimated 150,000 in its forests. The UK also has a small but well-entrenched boar population for the first time in 500 years.

Italy, well to the south, has always had wild boar, but has also seen a huge growth in their numbers. There are now estimated to be between 600,000 and 1 million animals. Some are seen on the outskirts of Rome, Genoa and Naples, where they eat from dustbins.

 


 

The paper:What Is a Mild Winter? Regional Differences in Within-Species Responses to Climate Change‘ by Sebastian G. Vetter, Thomas Ruf, Claudia Bieber, Walter Arnold is published in PLOS One.

Paul Brown writes for Climate News Network.

 

Roundup may cause potentially fatal ‘adrenal insufficiency’

Monsanto’s glyphosate-based herbicide Roundup is an endocrine (hormone) disruptor in adult male rats, a new study shows.

The lowest dose tested of 10 mg/kg bw/d (bodyweight per day) was found to reduce levels of corticosterone, a steroid hormone produced in the adrenal glands. This was only one manifestation of a widespread disruption of adrenal function.

No other toxic effects were seen at that dose, so if endocrine disruption were not being specifically looked for, there would be no other signs that the dose was toxic. However a 2012 study detected a 35% testosterone down-regulation in rats at a concentration of 1 part per million.

In both studies endocrine disruption was detected at the lowest level tested for, so we don’t know if, when it comes to endocrine disruption, there are ‘safe’ lower doses of Roundup. In technical parlance, this means that no NOAEL (no observed adverse effect level), was found.

Significantly, the authors believe that the hormonal disruption could lead to the potentially fatal condition know as ‘adrenal insufficiency‘ in humans, which causes fatigue, anorexia, sweating, anxiety, shaking, nausea, heart palpitations and weight loss.

“A progressive increase in its prevalence has been observed in humans, while a very few studies relating to xenobiotic exposure and adrenal insufficiency development have been reported”, they write. The increasing levels of Roundup in the environment and food could be “one of the possible mechanisms of adrenal insufficiency.”

How does this level relate to safety limits set by regulators?

One problem with trying to work out how the endocrine disruptive level of 10 mg/kg bw/d relates to how ‘safe’ levels are set by regulators.

The experiment looked at Roundup, the complete herbicide formulation as sold and used, but regulators only look at the long-term safety of glyphosate alone, the supposed active ingredient of Roundup.

Safe levels for chronic exposure to the Roundup herbicide product have never been tested or assessed for regulatory processes. This is a serious omission because Roundup has been shown in many tests to be more disruptive to hormones than glyphosate alone, thanks to the numerous other ingredients it contains to enhance its weed-killing properties.

Given this yawning data gap, let’s for a moment assume that the regulatory limits set for glyphosate alone can be used as a guide for the safe level of Roundup.

The endocrine disruptive level of Roundup found in the experiment, of 10 mg/kg bw/d, is is well above the acceptable daily intake (ADI) set for glyphosate in Europe (0.3 mg/kg bw/d) and the US (1.75 mg/kg bw/d). But this isn’t a reason to feel reassured, since with endocrine effects, low doses can be more disruptive than higher doses.

Another worrying factor is that 10 mg/kg bw/d is well below the NOAEL (no observed adverse effect level) for chronic toxicity of glyphosate: 500 mg/kg bw/d for chronic toxicity, according to the US EPA.

In other words, the level of 500 mg/kg bw/d – a massive 50 times higher than the level of Roundup found to be endocrine disruptive in the experiment – is deemed by US regulators not to cause chronic toxicity.

This experiment shows they are wrong by a long shot. They failed to see toxicity below that level because they failed to take endocrine disruptive effects from low doses into account and industry does not test for them.

Hormone disruption take place at or below ‘no adverse effects’ levels

Interestingly, the NOAEL for glyphosate in industry’s three-generation reproductive studies in rats was much lower than that for chronic toxicity – 30 mg/kg bw/day for adults and 10 mg/kg bw/day for offspring.

However the latter figures – at which no adverse effects should be apparent from glyphosate – are at the same as or higher level than the level of Roundup found to be endocrine disruptive in the new study.

These results therefore show that the reproductive processes of the rats are sensitive to low doses that are apparently not overtly toxic. This in turn suggests that the reproductive toxicity findings are due to endocrine disruptive effects.

Regulatory tests still do not include tests for endocrine disruption from low doses, in spite of the fact that scientists have known about the syndrome since the 1990s.

In the final section of the new study, the researchers discuss its implications. They note that the effects seen in the Roundup-treated rats to the Adrenocorticotropic hormone receptor (ACTH) were similar to adrenal insufficiency in humans:

“The findings that Roundup treatment down regulates endogenous ACTH, is similar to the condition known as adrenal insufficiency in humans. This condition manifests as fatigue, anorexia, sweating, anxiety, shaking, nausea, heart palpitations and weight loss. Chronic adrenal insufficiency could be fatal, if untreated.

“A progressive increase in its prevalence has been observed in humans, while a very few studies relating to xenobiotic exposure and adrenal insufficiency development have been reported. The present study describes one of the possible mechanisms of adrenal insufficiency due to Roundupand suggests more systematic studies, to investigate the area further. “

Claire Robinson of GMWatch commented: “Since no safe dose has been established for Roundup with regard to endocrine disrupting effects, it should be banned.”

 


 

The study:Analysis of endocrine disruption effect of Roundup in adrenal gland of male rats‘ is by Aparamita Pandey and Medhamurthy Rudraiah, and published in Toxicology Reports 2 (2015) pp.1075-1085 on open access.

This article was originally published by GMWatch. This version has been subject to some edits and additions by The Ecologist.